£68.00 (30ml)

How to Buy


PRETOX® Infin8
Professional Strength
Second Generation Injection-Free alternative to Botulinum Toxin treatment

Clinically proven to be 30% stronger than the corresponding Argireline® formulation, there is no more powerful topical muscle relaxant treatment. Contains 20% active ingredient in its complex form. This new super muscle relaxant ingredient - octapeptide, an elongation of the famous hexapeptide, Argireline®, is exclusive to Medik8. Designed for both men and women above their 40s onwards.

Infin8® is an effective and advanced way of reducing the appearance of dynamic wrinkles without the need of invasive techniques like injections or plastic surgery.

It offers a cosmetic solution against dynamic wrinkles based on an (exclusive to Medik8) 20% active ingredient called octapeptide. Octapeptide, which is an elongation of the famous hexapeptide – Argireline, stops the neurotransmitter release from reaching the muscle cell and effectively stops the muscle contraction. Rejuvenation of the face (by means of shallowing the depth of specific wrinkles) is an effect of continuous use, as is the smoothing effect on the skin. Infin8 contains the strongest available topical formula to chemically block the connections between nerves and local muscles. Clinically proven to be 30% stronger than the corresponding Argireline formulation, there is no more powerful topical muscle relaxant treatment.

Infin8 serum may be used as a supplement to professional Botulinum Toxin A treatment, but can also be a standalone treatment for an independent home use, bringing anticipated effects without the need for the invasive muscle paralysis treatment.


• Pretox® contains an inoffensive octapeptide composed of natural amino acids.
• It is a safer, cheaper and milder alternative to Botulinum Toxin treatment, targeting the same wrinkle forming mechanism in a very different way.
• Stimulates the skin fibroblasts in order to reconstitute the extracellular matrix.
• Leads to the synthesis of collagen I and IV, fibronectine and glycosaminoglycans (GAGs).
• Stimulates wound healing and gene expression, without the pro-inflammatory reactions of other treatments.
• Contains 20% Acetyl Octapeptide

Pretox Range

Injection Free is a specialist treatment cosmeceutical range based on the critical discoveries in the global beauty industry and Medik8’s own research. The gel formula reduces the appearance of all types of wrinkles: dynamic, static and wrinkle folds.

Dynamic wrinkles are formed as a result of facial muscles contractions. Thus the most common locations of dynamic wrinkles are on the forehead, on the outer corners of the eyes (the so called “crow’s feet”) and between the eyebrows. When muscles contract, they cause the overlaying skin to crumple and form lines. Probably the most effective and popular treatment against dynamic wrinkles is Botulinum Toxin A, also known as BOTOX. The treatment works by paralysing the muscles of facial expression, thus preventing their contraction and new lines from forming. Pretox Infin8  is a second-generation injection-free solution to anyone over their 40s onwards, who would like to obtain similar results to Botulinum Toxin A treatment, without drastic measures. Pretox Infin8 effectively rejuvenates the skin by working on all three layers of skin and on the muscular filaments, responsible for the facial expression.

In order to understand how Pretox works, it is essential to become familiar with how muscle contractions are stimulated. It is the attenuation or muting of muscle contraction in the facial muscle groups which allows wrinkles to ‘flatten out’ and become much less visible. Therefore, inhibition of the Snare Complex is the key to preventing the formation of dynamic wrinkles.

SNARE Complex

The nervous system and consequently the muscle contractions depend on chemical substances for communication among the various neurons and nervous fibres. These chemicals enable the brain to interpret signals (neurotransmitters) and produce a mechanical response (muscle contractions).

The neurotransmitter, usually an ACl anion, travels from the nerve to the muscle in a package called a ‘vesicle’.

Once the vesicle reaches the pre-synaptic membrane in the neuron, it releases the neurotransmitter, which is then adjoined by the SNARE complex receptor (a receptor composed of neuronal proteins).

The ACl anion’s binding with SNARE proteins releases a Na+ cataion which leads to depolarisation of the muscle cell membrane and muscle contraction.
However, if the reception of the SNARE complex is inhibited, the neurotransmitter signal cannot reach the muscle cell and the contraction is prevented. The second graph illustrates the process of neurotransmitter release in the skin treated with Argireline peptide solution. The ACl anion, travels from the nerve to the muscle in a ‘vesicle’. Once the vesicle reaches the pre-synaptic membrane in the neuron, it releases the neurotransmitter, which is then adjoined by the Argireline (hexapeptides).

The SNARE complex receptor remains closed, no Na+ cataions are released, depolarisation of the muscle cell membrane does not take place and the muscle stays relaxed. Clinical tests have shown that Pretox® inhibits the SNARE Complex in ageing skin.

Apply twice daily to clean, dry skin. Product should be used sparingly on targeted areas, avoiding upper & lower eyelids and lips.

Allow to absorb for 3-5 minutes before applying solution-based products, hydrator, sunscreen or make-up.

We endorse the use of sun protection. Pretox Infin8 may be used as a stand-alone treatment.

To view the application areas and protocol click below:

View the Medik8 Skin Zones

Highly compatible for use with Medik8 Titanium Dermaroller 0.2mm and 0.3mm
Aqua (Water), Acetyl Octapeptide-3, Alcohol Denat. (Ethanol B100), C12-15 Alkyl Benzoate, Glycerin, Xanthan Gum, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide -7, Palmitoyl Oligopeptide, Ceramide 2, PEG-10 Rapeseed Sterol, Butylene Glycol, Tribehenin, Steareth-20, Ethylhexylglycerine, Carbomer, Polysorbate 20, Phenoxyethanol, Lecithin

Patents Pending.

Key active highlights:

For full details on the key actives and bases, please see the Medik8 ingredient sheets or contact us for more information.

20% Acetyl Octapeptide - Elongation of the famous hexapeptide Argireline®.

Argireline® - Acetyl Hexapeptide-3

– Tetrapeptide acts like DHEA to reduce IL6 inflammatory response

– Pentapeptide stimulates production of collagen and elastin

Hyaluronic acid
– moisturising active that holds 1000x its own weight in water.


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White Balance™
Depigmentation Serum

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SPF Hydrator 25
(Normal to Dry Skin)

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Hydr8™ Body
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Go Back to Pretox Range

Medik8 is a pioneering skin research company working in the field of sensitive skin green cosmeceuticals. Results without the irritation! It is a myth that a product designed for sensitive skin would be less effective just because it is less irritating. In fact, latest independent research finds the opposite. Most skin is sensitive, it is just to what degree that distinguishes it from others. A simple change of washing powder can demonstrate this. People of all ages and skin types can periodically suffer from sensitive skin, making them particularly susceptible to certain irritating cosmeceutical ingredients. In fact, those suffering from acne, rosacea or psoriasis usually have greater skin sensitivity. Medik8 also recognise that people with sensitive skin and redness can also have oily, dry or combinations skin which is why our range for sensitive skin encompasses all skin types rather than offering one sensitive option. The challenge for Medik8 is to make effective professional skincare formulae less aggressive without reducing potency. We do this in many ways, for example using film-encapsulation, chirally correct actives, non-acid derivatives and patented anti-erythema technologies.